FMOC-Glycine NEW

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Min. Order1kg
Purity98%min
Cas No29022-11-5
Supply Ability1000kg
Update time2025-12-31

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Chemical Properties

Product Name	FMOC-Glycine
CAS No	29022-11-5
EC-No	249-373-3
Min. Order	1kg
Purity	98%min
Supply Ability	1000kg
Release date	2025/12/31

FMOC-Glycine Cas 29022-11-5

Specification

Items	Specifications	Results
Appearance	White to off-white powder	White powder
Purity(HPLC)	≥99%	99.71%
TLC	≥98%	>98%
Melting Point	165-185 ℃	175.3-175.7 ℃
Clarity of solution	0.3 gram in 2ml DMF clear solution	Complies
Water Content(K.F.)	≤1.0%	0.19%
Element analysis(C、H、N)	≤5.0%	<5.0%
Loss on drying	≤1.0%(60 ℃,2h)	0.10%
Kaiser Test	<0.05%	<0.05%
IR Spectrum	In accordance with the structure	Complies
Mass Spectrum	In accordance with the structure	Complies
NMR Spectrum	In accordance with the structure	Complies
Conclusion	It meets the quality inspection standards.

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Fmoc-Gly-OH is a protected amino acid derivative used primarily in solid-phase peptide synthesis (SPPS). Its name breaks down as follows:

Gly: This is the standard three-letter abbreviation for the amino acid Glycine. It is the simplest amino acid, with a hydrogen atom as its side chain.

Fmoc: Stands for Fluorenylmethyloxycarbonyl. This is a protecting group that blocks the amine group (-NH₂) of the glycine molecule.

-OH: Indicates that the carboxylic acid group (-COOH) of the glycine is free and reactive.

Primary Function and Use

In peptide synthesis, amino acids are linked together by forming a bond between the amine group of one and the carboxylic acid group of another. To prevent unwanted reactions, the amine group must be "protected."

Fmoc-Gly-OH is the building block for incorporating glycine into a growing peptide chain. The Fmoc group protects Glycine's amine functionality during the coupling process. Once the glycine is attached to the chain, the Fmoc group can be easily and selectively removed using a mild base (like piperidine), exposing the amine group so it can react with the next protected amino acid.

Key Characteristics

Orthogonal Protection: The Fmoc group is stable to acids but easily removed by base. This allows it to be used alongside other acid-labile protecting groups, offering chemists flexibility in synthesizing complex peptides.

Crystallinity: Fmoc-Gly-OH is typically a white, crystalline solid, making it easy to handle, store, and measure accurately in the lab.

Essential Reagent: It is a fundamental and widely used reagent in pharmaceuticals, biochemistry, and research for creating custom peptides and peptide-based drugs.

In summary, Fmoc-Gly-OH is not a drug or a supplement, but a crucial tool for chemists to manually construct peptide molecules, one amino acid at a time.

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