Product Name: Sofosbuvir
Synonyms: GS-7977;N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;PSI 7977;sofosbuvir;GS-7977/sofosbuvir;sofosbuvir, PSI7977;(S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(phenoxy)phosphoryl)aMino)propanoate;PSI-7977 Discontinued
Molecular Formula: C22H29FN3O9P
Molecular Weight: 529.4525242
CAS No.: 1190307-88-0
Appearance: white crystalline powder
Puity: 99.0% up by HPLC
Usage: treat for chronic hepatitis C
sofosbuvir is first without joint interferon can be safe and effective drug for the treatment of certain types of hepatitis c.Clinical trials confirm for type 1 and 4 c, the drug combination of polyethylene glycol (peg) interferon and ribavirin overall sustained virological response (SVR) is as high as 90%;In view of the type 2 c, the drug plus ribavirin SVR is 89% - 95%;In view of the 3 c, the drug plus ribavirin SVR is 61% - 63%.
Function
sofosbuvir is a kind of hepatitis c virus (HCV) NS5B polymerase inhibitors nucleotide analogues, applicable to as united antiviral treatment composition in the treatment of chronic hepatitis c (CHC) infection.
sofosbuvir confirmed by test can effectively treat genotype 1, 2, 3, or 4 c subjects, including within milan criteria are awaiting liver transplantation of HCC subjects and co-infection of HCV/HIV - 1 subjects.
China
