Calcipotriol Monohydrate Cas 147657-22-5
Specification
Items | Specification | Result |
Appearance | White powder | White powder |
Purity | ≥97.5% | 99.10% |
Water | ≤5.0% | 2.2% |
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Calcipotriol Monohydrate is a synthetic analog of vitamin D₃ (cholecalciferol) engineered to retain therapeutic potency while minimizing the hypercalcemic side effects of natural vitamin D. Chemically, it differs from endogenous vitamin D₃ by a hydroxyl group at the 24-position and a double bond in the side chain, optimizing its affinity for vitamin D receptors (VDRs) in skin cells.
Mechanistically, it exerts anti-psoriatic effects by binding to VDRs in keratinocytes and immune cells: it inhibits abnormal keratinocyte proliferation, promotes normal differentiation (restoring skin barrier function), and suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-6) and immune cell infiltration—addressing the core pathogenic features of psoriasis.
Clinically, it is a first-line topical therapy for mild-to-moderate plaque psoriasis, available as ointments, creams, gels, or foams for targeted application to lesions (scalp, body). It is often combined with topical corticosteroids (e.g., betamethasone) to enhance efficacy and reduce irritation. Beyond psoriasis, it is being investigated for other hyperproliferative skin conditions (e.g., vitiligo, ichthyosis) due to its regulatory effects on skin cell turnover.
Formulation-wise, it requires stability considerations (protected from light/heat) and is formulated for low systemic absorption, ensuring safety for long-term use. Its role in dermatology underscores its value as a targeted, patient-friendly alternative to systemic therapies for chronic skin disorders.
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Contact information
Spring Zhang
Email: export@fortunachem.com
Skype: Fortunachem201304
QQ:3169620873
Tel: +86-27-59207892
Website: www.fortunachem.com
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