| Name | 1,4-DPCA |
| Description | 1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH). |
| In vitro | 1,4-DPCA significantly reduces the colony sizes and invasive branches of T4-2 (10 μM) and ZR-75-1 cells (20 μM). 1,4-DPCA inhibits the proliferation in T4-2, ZR-75-1, MDA-MB-231 cells, and MDA-MB-157[1]. In mouse B6 cells, 1,4-DPCA specifically increases the expression of proangiogenic target genes including Hmox1 and Vegfa, and proglycolytic targets including Ldh-a, Pdk1, Glut1, and Pgk1[2]. |
| In vivo | In mice, 1,4-DPCA effectively inhibits collagen deposition within and on the outer surface of the disc, and limits connective tissue ingrowth. 1,4-DPCA suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) discs implanted in the peritoneal cavity[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 2.78 mg/mL (11.56 mM), Sonication is recommended.
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| Keywords | HIF-PH | HIF/HIF Prolyl-Hydroxylase | HIF-1α | HIFs | FIH | P4HA1 | P4HA2 | 1,4DPCA | healing | 1,4-DPCA | Inhibitor | Hypoxia-inducible factors | 1,4 DPCA | wound | inhibit | P4HA3 |
| Inhibitors Related | Deferoxamine Mesylate | Hydralazine hydrochloride | DMOG | PT-2385 | Chlorogenic Acid | Roxadustat | Glucosamine | Hydroxycitric acid tripotassium hydrate | Glucosamine hydrochloride | Minocycline hydrochloride | Oltipraz | Glucosamine sulfate |
| Related Compound Libraries | Glycolysis Compound Library | Bioactive Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
United States
