Cimetidine Cas 51481-61-9
Specification
Items | Specification | Result |
Appearance | White or almost white crystalline powder | Complies |
Assay | ≥99.0% | 100.0% |
Loss on drying | ≤0.5% | 0.19% |
Residue on ignition | ≤0.1% | Complies |
Heavy metals | ≤10ppm | <10ppm |
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Cimetidine is a medication that belongs to a class of drugs called H2 (histamine-2) receptor blockers. It was one of the first widely successful drugs of its kind, marketed under the brand name Tagamet.
How It Works
Its primary function is to reduce the production of stomach acid. It achieves this by blocking histamine from stimulating the acid-producing cells (parietal cells) in the stomach lining. Less acid means:
Relief from heartburn (acid reflux)
Healing of stomach and duodenal ulcers
Reduction of symptoms in conditions like GERD (Gastroesophageal Reflux Disease)
Common Uses
Cimetidine was historically prescribed to treat:
Peptic ulcers (both gastric and duodenal)
GERD
Conditions where reducing stomach acid is beneficial (e.g., Zollinger-Ellison syndrome)
Important Considerations
"The Prototype": Cimetidine was a groundbreaking drug, but it has largely been replaced by newer H2 blockers (like famotidine/Pepcid) and Proton Pump Inhibitors (PPIs like omeprazole/Prilosec), which are often more effective and have fewer side effects.
Key Side Effect: It is known for a higher likelihood of drug interactions because it inhibits liver enzymes (cytochrome P450) responsible for metabolizing many other common medications (e.g., blood thinners, some antidepressants). This can lead to increased levels of those drugs in the body.
Other Potential Effects: It has anti-androgen effects and, with long-term high-dose use, was sometimes associated with gynecomastia (enlarged breast tissue in men) and impotence.
In summary, cimetidine is a pioneering stomach acid-reducing medication that is now used less frequently due to newer drugs with better safety profiles and fewer interactions.
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* L/C
Contact information
Spring Zhang
Email: export@fortunachem.com
Skype: Fortunachem201304
Wechat/Whatsapp: 18007136271
Tel: +86-27-59207892
Website: www.fortunachem.com
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