Amikacin Disulfate Cas 39831-55-5
Specification
Items | Specification | Result |
Appearance | White crystalline powder | Complies |
Assay | 691-806 μg/mg | 749μg/mg |
Loss on drying | ≤13% | 4.65% |
Residue on ignition | ≤1.0% | 0.07% |
Sterility | Should meet the requirement | Complies |
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Amikacin Disulfate is a salt form of the antibiotic amikacin, specifically where the amikacin base is combined with two sulfate groups. It is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.
Primary Uses:
Amikacin disulfate is a potent, broad-spectrum antibiotic used almost exclusively in hospital settings for serious, often life-threatening infections, particularly those caused by Gram-negative bacteria. Its major uses include:
Treatment of Resistant Infections: It is a key drug for infections resistant to other aminoglycosides (like gentamicin or tobramycin) and other antibiotics, due to its stability against many bacterial-inactivating enzymes.
Gram-Negative Bacilli Infections: Used for severe infections caused by bacteria such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella, and Acinetobacter. Common infection sites include:
Complex urinary tract infections
Bloodstream infections (sepsis)
Pneumonia (especially hospital-acquired/ventilator-associated)
Post-surgical or intra-abdominal infections
Mycobacterial Infections: It is a second-line drug in the treatment of multidrug-resistant tuberculosis (MDR-TB).
Combination Therapy: Often used in combination with a beta-lactam antibiotic (like a penicillin or cephalosporin) for synergistic effect and to broaden coverage, especially in febrile neutropenia or empirical treatment of severe sepsis.
Key Administration & Safety Notes:
Route: Administered only by intravenous (IV) infusion or intramuscular (IM) injection.
Critical Monitoring: Requires careful therapeutic drug monitoring (measuring peak and trough blood levels) due to its narrow therapeutic index.
Major Toxicities: The two main dose-limiting side effects are:
Nephrotoxicity (kidney damage)
Ototoxicity (irreversible damage to the inner ear, leading to hearing loss and/or balance disturbances).
In summary, amikacin disulfate is a powerful, last-line injectable antibiotic reserved for severe, resistant bacterial infections in controlled hospital settings, where its benefits are weighed against significant potential toxicity.
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Contact information
Spring Zhang
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Tel: +86-27-59207892
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