N-Acetylcysteine Ethyl Ester

$ 1.00 /1g

Min. Order1g
Purity99%
Cas No59587-09-6
Supply Ability1000kgs/month
Update time2024-02-22

Hubei Langyou International Trading Co., Ltd

4YR

China

Chemical Properties

Product Name	N-Acetylcysteine Ethyl Ester
CAS No	59587-09-6
EC-No
Min. Order	1g
Purity	99%
Supply Ability	1000kgs/month
Release date	2024/02/22

High Purity N-Acetylcysteine Ethyl Ester CAS 59587-09-6

Product Name: NACET N-Acetyl-L-cysteine ethyl ester
Synonyms:
N-Acetyl-L-cysteine ethyl ester;L-Cysteine, N-acetyl-, ethyl ester;N-Acetylcysteine ethylester;(R)-ethyl 2-acetaMido-3-Mercaptopropanoate;(R)-Methyl 2-acetaMido-3-Mercaptopropanoate;-Ethyl 2-acetamido-3-mercaptopropanoate
CAS No.: 59587-09-6
Molecular Formula: C7H13NO3S
Molecular Weight: 191.24
Appearance: white Fine powder
Capacity: 1000kgs per month
Source: synthetic
Purity (HPLC) >99.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat.

What is N-Acetyl-L-cysteine ethyl ester?

N-Acetyl-L-cysteine ethyl ester powder 59587-09-6, is natural or synthetic substances that can enhance brain function, to improve mental performance in healthy people. Usually known as Nootropics and smart drugs, they have gained popularity in today's highly competitive society and are most often used to boost memory, focus, creativity, intelligence and motivation.

N-Acetyl-L-cysteine ethyl ester Benefits

Recent large clinical trials failed to confirm the supposed beneficial effects of N-acetylcysteine (NAC) in preventing oxidative stress-related diseases. This may be due to its low bioavailability. We thought that esterification of the carboxyl group of NAC to produce N-acetylcysteine ethyl ester (NACET) would drastically increase the lipophilicity of NAC, thus greatly improving its pharmacokinetics. In the present work, we report on representative chemical, pharmacological and anti-oxidant properties of NACET, especially in direct comparison with its congener NAC.

We found that NACET is rapidly absorbed in rats after oral administration but reaches very low concentrations in plasma. This is due to a unique feature of NACET: it rapidly enters the cells where it is trapped being transformed into NAC and cysteine. After oral treatment, NACET (but not NAC) was able to increase significantly the glutathione content of most tissues examined, brain included, and to protect from paracetamol intoxication in the rat. NACET has also the unique feature to accumulate in human erythrocytes where it behaves as a potent protector against hydroperoxide-induced oxidative damage.

Our study shows that being able to enter cells and to produce NAC and cysteine, NACET increases circulating hydrogen sulfide (H(2)S), thus representing a good candidate for the oral use as an H(2)S producer, with clear advantages over NAC. NACET has the potential to substitute NAC as a mucolytic agent, as a paracetamol antidote and as a GSH-related antioxidant.

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