Sodium new houttuyfonate (SNH), is an addition product of active ingredient houttuynin which could inhibit a variety of bacteria. Sodium new houttuyfonate (SNH) contains a hydrophilic sulfinyl head and a hydrophobic alkyl tail with 12 carbon atoms, which is considered to be surfactant-like structure. Although antibacterial mechanism of SNH remains unknown, it was indicated that Sodium new houttuyfonate (SNH) exerted its antimicrobial effect mainly through binding of non-polar tail group to bacterial hydrophobic membrane proteins or cytoplasmic enzymes. The hydrophobic lipid bilayer of cell membrane might be another target of aliphatic chain of SNH.
SNH was reported to exhibit potent inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, and Klebsiella pneumoniae, etc
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