Celecoxib

CAS: 169590-42-5

MF: C17H14F3N3O2S

MW: 381.37

EINECS: 685-962-5

Melting point 157-159°C

Boiling point 529.0±60.0 °C(Predicted)

density 1.43±0.1 g/cm3(Predicted)

storage temp. Store at RT

solubility DMSO: >20mg/mL

pka 9.68±0.10(Predicted)

form powder

color white to off-white

Water Solubility 7mg/L(25 ºC)

Celecoxib and Rofecoxib are two currently used COX-2 inhibitors. Successfully developed by GD Searle & Pfizer Co. (U.S.,) released in 1999, trade name: Celebrex.

Celecoxib is a nonsteroidal, anti-inflammatory agent with significant analgesic and anti-inflammatory effects, causing the lowest incidence of upper gastrointestinal tract ulcers and other complications. Used clinically to treat acute and chronic osteoarthritis and rheumatoid arthritis, with an anti-inflammatory analgesic role, relieving the signs and symptoms of osteoarthritis and rheumatoid arthritis.