Norcantharidin is a synthetic derivative of cantharidin, which can improve the respiratory control rate and lysosomal enzyme activity of cancer cells, interfere with the division of cancer cells, inhibit the synthesis of DNA, and act on the M phase of cell cycle. After absorption, the product is mainly distributed in liver, intestine, kidney, heart, lung, salivary gland, thyroid and other tissues. Clinically, it is mainly used for the treatment of primary liver cancer, esophageal cancer, gastric and cardiac cancer and leukopenia; It can also be used in combination chemotherapy to treat various tumors, antagonize the myelosuppression of other anticancer drugs and improve the curative effect. It can also be used in the treatment of hepatitis B. According to clinical reports in recent years, cantharidin, cantharidin or hydroxycantharidin have significant effects in the treatment of primary liver cancer, viral hepatitis, rhinitis, tracheitis, etc. However, cantharidin is highly toxic and can cause skin redness, tingling and blistering when touched. Therefore, both internal and external use should be cautious.
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