Specification
| Appearance |
white or yellowish-white, microfine powder |
Melting point | Soluble in water and acetic acid |
Appearance of solution | The solution is clear and not more intensely coloured than reference solution Y4. |
Specific optical rotation | +354°to +364° |
Loss on drying | ≤1.0 |
Peptide Purity (By HPLC) |
97.0% to 102.0% |
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(+)-Griseofulvin is the biologically active, naturally occurring enantiomer of griseofulvin, an antifungal compound produced by the mold Penicillium griseofulvum. It is classified as a benzofuran spiro compound.
Primary Use: Antifungal Medication
Its main and historical use is as a systemic antifungal drug to treat dermatophyte infections of the skin, hair, and nails (e.g., ringworm, tinea capitis, onychomycosis).
Key Characteristics & Mechanism
Fungistatic: It inhibits fungal growth.
Mechanism: It selectively disrupts fungal microtubule formation during mitosis, arresting cell division. It also accumulates in keratin precursor cells, making newly formed skin, hair, and nails resistant to fungal invasion.
Spectrum: Effective only against dermatophytes (Microsporum, Trichophyton, Epidermophyton).
Other Uses
Veterinary Medicine: Used to treat similar fungal infections in animals.
Plant Protectant: Serves as a fungicide in agriculture, particularly against certain plant pathogenic fungi like Botrytis.
Current Status
While once a first-line oral treatment, its use in human medicine has declined significantly in favor of newer, broader-spectrum antifungals (like terbinafine and azoles) that have shorter treatment durations and better side-effect profiles. It remains a useful agent in specific cases and a classic example of a natural product antifungal.
In summary, (+)-Griseofulvin is a classic oral antifungal drug derived from mold, specifically used to treat ringworm and nail infections by disrupting fungal cell division, though its clinical use is now limited.
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