Domperidone

Domperidone is a commonly used gastric motility drug and antiemetic drug. One of its names is domperidone, and its other aliases are propanedione, imipradone, droperidone, weideling, ludeline, droperidone, piperidine, propanediphenyl ether, etc. its appearance is white to yellowish powder. It tastes bitter, almost insoluble in water, slightly soluble in ethanol, and easily soluble in lactic acid, It is soluble in citric acid. This product is a strong peripheral dopamine receptor antagonist. Domperidone can block DA1 and DA2 receptors before and after synapses, and antagonize the inhibition of dopamine on postsynaptic cholinergic neurons in the intestinal plexus and cause gastric contraction. It can promote the peristalsis and tension of upper digestive tract to return to normal, promote gastric emptying, increase the movement of gastric antrum and duodenum, coordinate the contraction of pylorus, and enhance the peristalsis of esophagus and the tension of lower esophageal sphincter