English name: Quetiapine fumarate
CAS Number: 111974-72-2
Molecular formula: C46H54N6O8S2
Molecular weight: 883.09
EINECS number:1308068-626-2
Antipsychotics:
Quetiapine fumarate is an antipsychotic drug, which was successfully developed by AstraZeneca in the United States. It interacts with a variety of neurotransmitter receptors. In the brain, it has a high degree of serotonin (5-HT2) receptors. The affinity antipsychotic drug quetiapine fumarate is an antipsychotic drug, which was successfully developed by AstraZeneca in the United States. It interacts with a variety of neurotransmitter receptors. In the brain, it has an effect on serotonin (5-HT2). The receptor has a high affinity and is greater than the affinity for dopamine D1 and dopamine D2 receptors in the brain. Quetiapine also has high affinity for histamine H1 receptors and adrenergic α1 receptors, and has low affinity for adrenergic α2 receptors, but has low affinity for cholinergic Chemicalbook muscarinic receptors or benzodiazepine receptors. Basically no affinity. The activity of antipsychotic drugs, such as the conditional avoidance reflex, was positive. Clinically, it is mainly used for the treatment of adult major depression, acute manic episodes of bipolar disorder and various types of schizophrenia. It is not only effective for positive symptoms of schizophrenia, but also for negative symptoms. It can also alleviate the affective symptoms associated with schizophrenia such as depression, anxiety and cognitive deficit symptoms. , And greater than the affinity for dopamine D1 and dopamine D2 receptors in the brain. Quetiapine also has high affinity for histamine H1 receptors and adrenergic α1 receptors, and has low affinity for adrenergic α2 receptors, but has low affinity for cholinergic Chemicalbook muscarinic receptors or benzodiazepine receptors. Basically no affinity. The activity of antipsychotic drugs, such as the conditional avoidance reflex, was positive. Clinically, it is mainly used for the treatment of adult major depression, acute manic episodes of bipolar disorder and various types of schizophrenia. It is not only effective for positive symptoms of schizophrenia, but also for negative symptoms. It can also alleviate the affective symptoms associated with schizophrenia such as depression, anxiety and cognitive deficit symptoms.
China
