Tropicamide Cas 1508-75-4
Specification
Items | Specification | Result |
Appearance | White powder | White powder |
Assay | 99%-101% | 99.7% |
Loss on drying | ≤0.5% | 0.05% |
Residue on ignition | ≤0.05% | Complies |
Heavy metals | ≤0.002% | Complies |
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Tropicamide (CAS 1508-75-4) is a synthetic anticholinergic agent (muscarinic antagonist) with the chemical formula C₁₇H₂₁NO₃. It acts by blocking acetylcholine receptors in the eye’s iris and ciliary muscle, inducing mydriasis (pupil dilation) and cycloplegia (temporary paralysis of accommodation).
Key Uses:
Ophthalmology:
Diagnostic Procedures: Gold standard for dilating pupils to examine the retina, optic nerve, and posterior eye structures (e.g., during eye exams for glaucoma, macular degeneration).
Refraction Testing: Induces cycloplegia to measure accurate refractive errors (nearsightedness/farsightedness) in children or patients with accommodative spasm.
Preoperative Preparation: Dilates pupils before eye surgeries (e.g., cataract, retinal detachment repair) to improve surgical access.
Veterinary Medicine:
Used to dilate pupils in animals (dogs, cats, horses) for ophthalmic exams or preoperative care, with dosage adjusted for species and weight.
Formulations & Advantages:
Available as ophthalmic drops (0.5%, 1% concentrations) with rapid onset (15–30 minutes for mydriasis, 30–60 minutes for cycloplegia) and short duration (4–8 hours), minimizing patient discomfort (e.g., blurred vision, light sensitivity).
Safety Notes:
Contraindicated in glaucoma patients (risks increased intraocular pressure). Temporary side effects may include blurred vision, photophobia, or dry eyes. Use cautiously in children and elderly—monitor for systemic effects (e.g., flushing, tachycardia) with excessive exposure.
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