Monosialoganglioside GM1
Specification
Items | Specification | Result |
Appearance | White or almost white powder | White powder |
Assay | ≥96% | 99.2% |
Purity(HPLC) | ≥99% | 99.6% |
Total sialic acid | 19%-21% | 20.2% |
Water | ≤5.0% | 3.0% |
Heavy metals | ≤20ppm | <20ppm |
Residue on ignition | ≤5.0% | Complies |
Welcome to contact with us to get more information.
Ganglioside GM (typically referring to GM1) is a glycolipid naturally found in the membranes of mammalian nerve cells. Clinically, it is primarily used as a prescription drug in the form of Monosialotetrahexosylganglioside (GM1). Its core function is to serve as a neuroprotective agent, providing adjunctive treatment for injuries to the central nervous system (brain and spinal cord).
Definition
Nature: It is a glycolipid component naturally found in cell membranes, particularly abundant in the nervous system .
Source: Clinical formulations are typically extracted from pig brains .
Function: It is involved in the growth, differentiation, and repair of nerve cells .
Clinical Indications
In clinical practice, GM1 is primarily used as an adjunctive treatment for the following conditions :
Central Nervous System (CNS) Injury: Treatment of vascular (e.g., stroke) or traumatic (e.g., brain/spinal cord injury) CNS injuries .
Parkinson's Disease: Used to help improve behavioral disorders and symptoms associated with Parkinson's disease .
Peripheral Neuropathy: Occasionally used for the treatment of peripheral nerve diseases .
Mechanism of Action
Neuroplasticity: It promotes "neuroplasticity," including the survival of nerve cells, axonal growth, and synaptogenesis .
Neuroprotection: It protects against secondary neurodegeneration after injury and reduces nerve cell edema by improving cell membrane enzyme activity .
Blood-Brain Barrier: It has a high affinity for nerve tissue and can cross the blood-brain barrier to reach the site of nerve injury .
Important Safety Warning
Guillain-Barré Syndrome (GBS): There is a serious risk of developing GBS, a condition where the immune system damages nerve cells, causing muscle weakness and paralysis. Patients must be monitored for symptoms like limb weakness or difficulty holding objects .
Controversy & Regulation: While widely used in some regions, its efficacy is debated in international guidelines, and it is strictly monitored due to safety concerns .
Summary: Ganglioside GM is a prescription medication used to aid nerve recovery after brain/spinal injury or for Parkinson's disease, but it carries significant risks and requires strict medical supervision.
Packages
Delivery
Payment term
* Wire Transfer/Telegraphic Transfer
* Western Union
* MoneyGram
* L/C
Contact information
Spring Zhang
Email: export@fortunachem.com
Skype: Fortunachem201304
QQ:3169620873
Tel: +86-27-59207892
Website: www.fortunachem.com
China
