ISRIB (trans-isomer)

this study found that an experimental drug, ISRIB, may have a wide range of effects on neurological disorders, improving or even reversing neurological disorders such as Alzheimer’s disease, Parkinson’s disease, Down’s syndrome, amyotrophic lateral sclerosis (ALS), and age-related cognitive decline.

ISRIB was tested to see whether it would be active in vivo, and was found to readily cross the blood-brain barrier, with a half-life of 8 hours. Subsequent testing in 2013 found ISRIB to produce significant nootropic effects in mice, as measured by enhancement of spatial and fear-associated learning in standard water maze and conditioned environment tests. Testing in 2017 indicated the experimental drug improved the ability of brain-injured mice to learn and form memories on memory tests, thus appearing to reverse impairments from traumatic brain injury.ISRIB treatment also corrects spatial memory deficits and improves working memory in aged mice

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