Name | 1,3-Dicaffeoylquinic acid |
Description | 1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent. |
Animal Research | The neuroprotective effects of 1,5-DQA against amyloid β(1-42) (Aβ(42))-induced neurotoxicity in primary neuronal culture. To evaluate the neuroprotective effects of 1,5-DQA, primary cultured cortical neurons from neonate rats were pretreated with 1,5-DQA for 2 hours and then treated with 40 μmol/L Aβ(42) for 6 hours. Cell counting kit-8, Hoechst staining and Western blotting were used for detecting the protective mechanism. Comparisons between two groups were evaluated by independent t test, and multiple comparisons were analyzed by one-way analysis of variance (ANOVA). |
In vivo | CYNARIN have neuroprotective effects.CYNARIN prevents Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 23 mg/mL (44.53 mM)
|
Keywords | Phosphoinositide 3-kinase | 1,3 Dicaffeoylquinic acid | PI3K | Akt | inhibit | Protein kinase B | Inhibitor | 1,3Dicaffeoylquinic acid | PKB | 1,3-Dicaffeoylquinic acid | Reactive Oxygen Species |
Inhibitors Related | Sodium Thiocyanate | Imeglimin hydrochloride | Myricetin | L-Ascorbic acid | α-Vitamin E | Glucosamine | D-(+)-Glucono-1,5-lactone | Artemisinin | Lycopene | Coenzyme Q10 | Naringenin | 2,3-Butanediol |
Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Kinase Inhibitor Library | Natural Product Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Neuroprotective Compound Library | Natural Product Library for HTS | Ancient Chinese Classical Formulas Compound Library |