Product Description
Product Description
Clozapine appears as pale yellow crystalline powder. It is odorless, tasteless with a molecular weight of 326.83 and a melting point 183~184 °C. It is soluble in chloroform, ethanol but insoluble in water.
This product is a non-classical antipsychotic which can selectively block DA receptors of the mesolimbic system but has a small effect on the nigrostriatal DA receptors. It has a relatively weak blocking effect on D2 receptor, but a strong blocking effect on D1 receptors strong while also has some antagonist effect on D4 receptor and 5-HT2 receptor. Thereby, it has strong anti-psychotic effects. Moreover EPS is less common and does not cause stiff reaction. Owing to the direct inhibition effect on the ascending reticular activating system of the brains, it has a potent sedative and hypnotic effects which can well applied for treating schizophrenia, hallucinations, delusions and youth-based effect. In addition to its good efficacy on treating positive symptoms like agitation, hallucinations, and paranoia, it also has a good efficacy on the negative symptoms. Since this product has a different mechanism of action on blocking DA receptors with traditional antipsychotics, thus this drug may also be effective in treating some classic antipsychotic disease which fails be treated with traditional drugs. It can also be used to alleviate mania and severe sleep disorders. In addition, it also has an anti-cholinergic effect. NE has sympathetic blocking effect, muscle relaxing effect and anti-histamine effect.
Specification
Items | Specification | Result |
Appearance | Yellow crystalline powder | Yellow crystalline powder |
Identification | Positive | Positive |
Melting point | 182 ~ 186 | 183.5 ~ 185.5 |
Related substances | Impurity A NMT 0.1% | 0.01% |
Impurity B NMT 0.2% | 0.03% |
Impurity C NMT 0.3% | 0.04% |
Impurity D NMT 0.2% | 0.02% |
Unspecified impurity NMT 0.1% | 0.01% |
Total impurity NMT 0.6% | 0.1% |
Heavy metals | NMT0.002% | NMT0.001% |
Loss on drying | NMT 0.5% | 0.03% |
Sulfate ash | NMT 0.1% | 0.02% |
Assay | 99.0 ~ 101.0% | 99.6%
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Packing & Shipping
Company Profile
Welcome to Hebei Guanlang Biotechnology Co.Ltd (Guanlang)
Guanlang is a fast growing intermediates company,Which located in Shijiazhuang,Hebei Province.Our main product is chlorine dioxide, Sodium dichloroisocyanurate(sdic or nadcc) ANDTrichloroisocyanuric acid (TCCA)for water treatment.We also supply raw materials for detergent and hand sanitizer products,such as carbopol 940,carbopol stock solution,Hydroxypropyl methyl cellulose (HPMC) and so on.
Guanlang also supply various industrial chemicals for customers, such as citric acid,potassium chloride etc.After ten years development,Crovell has become a Diversified development company,not only involves in chemicals, but also real estate ,agricultural products and so on.So far, Crovell has usiness in more than 35 countries,most big customers come from europe and America, because among the suppliers in China.
Guanlang can always make the product quality best, some of the products from Guanlang can reach the purity of 99.9+, such as 2-phenylacetamide. This is the important reason for customers who choosing Guanlang.In future, Crovell must become to a more important trade bridge for china and foreign countries especially in pharmaceutical industries.
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why choose our company
1. quality
our products meet msds safe standard and we have iso and other certificate so yan can get high quality products from our company.
2. price
we are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.
3.packing
we can do according to the customers' request.
4.transport
ems,dhl, tnt, ups ,fedex, by air, by sea
dhl express, fedex and ems for quantity less than 50kg, usually called as ddu service;
sea shipping for quantity over 500kg; and air shipping is available for 50kg above;
for high value products, please select air shipping and dhl express for safe;
5.service
we offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes
us able to offer you one-stop service from the order to the products transported to your hand.
we will try our best to satisfied you.
1. tailor-made for every customers.
2. third-party test for the products you demand.
3. test your counter-samples and produce them for you.
4. best discount for old customers.
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