Description of Brinzolamide
Brinzolamide is a carbonic anhydrase inhibitor (specifically, carbonic anhydrase II). Carbonic anhydrase is found primarily in erythrocytes (but also in other tissues including the eye). It exists as a number of isoenzymes, the most active of which is carbonic anhydrase II (CA-II).
Specification of Brinzolamide
TEST | SPECIFICATIONS |
Appearance | White crystalline powder |
Idetification | 1 | Should meet the requirement |
| 2 | Shoule meet the requirement |
Impurity A | ≤0.5% |
Impurity B | ≤0.3% |
Max individual unknown impurity | ≤0.1% |
Total impurity | ≤1.0% |
Loss on drying | ≤0.5% |
Residue on ignition | ≤0.1% |
Heavy metal | ≤20ppm |
Assay | 98.0%~102.0%(Calculated on the dried basis) |
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