Benzonatate

$ 1.80 /1KG

Min. Order1g
Purity96%-99%
Cas No104-31-4
Supply Ability1kg/10kg/100kg
Update time2024-10-22

Career Henan Chemica Co

5YR

China

Chemical Properties

Product Name	Benzonatate
CAS No	104-31-4
EC-No
Min. Order	1g
Purity	96%-99%
Supply Ability	1kg/10kg/100kg
Release date	2024/10/22

Email: amy@coreychem.com
Career Henan Chemical Co
Mob/Skype: +86-18317388371

Benzonatate Basic information

Product Name:	Benzonatate
Synonyms:	4-(Butylamino)benzoicacid3,6,9,12,15,18,21,24,27-nonaoxao-ctacos-1-ylester;benzoicacid,4-(butylamino)-,3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yles;benzononantin;benzononatine;tessalon;tessalon-ciba;thoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylester;ventussin
CAS:	104-31-4
MF:	C30H53NO11
MW:	603.74
EINECS:	203-194-7
Product Categories:	Chemical Amines;Amines;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	104-31-4.mol

Benzonatate Chemical Properties

Boiling point	649.0±55.0 °C(Predicted)
density	1.096±0.06 g/cm3(Predicted)
pka	2.20±0.39(Predicted)
CAS DataBase Reference	104-31-4(CAS DataBase Reference)

Safety Information

Toxicity

LD50 oral in mouse: 400mg/kg

MSDS Information

Benzonatate Usage And Synthesis

Originator	Tessalon,Endo (Du Pont),US,1958
Uses	Antitussive
Definition	ChEBI: The ester obtained by formal condensation of 4-butylaminobenzoic acid with nonaethylene glycol monomethyl ether. Structurally related to procaine and benzocaine, it has an anaesthetic effect on the stretch sensors in the lungs, and is used as a non-narcoti cough suppressant.
Manufacturing Process	4.42 parts of para-butylamino-benzoic acid ethyl ester are put with 16.0 parts of a mixture of polyethylene glycol monomethyl ethers, boiling at 180°-220°C at a pressure of 0.01 mm of mercury, in a closed reaction vessel which is fitted with an adjustable inlet tube for solvents and a connection for distilling off in vacuo. In order to dry the mixture completely, it is heated for an hour at 100°-105°C and absolute xylene is introduced under the surface of the mixture in vacuo at a pressure of 12 mm of mercury. There is thus a constant stream of xylene steam passing through the whole apparatus, which removes the last traces of moisture and any other volatile impurities. The xylene is condensed in a cooler. The whole is cooled to 20°-30°C and 0.06 part of sodium methylate dissolved in 0.6 part of methanol is added. Thereupon xylene is introduced again in vacuo at a temperature of 100°- 105°C whereby all the methanol and the ethanol formed during reesterification evaporates. The re-esterification is continued under these conditions until a specimen of the reaction mass is clearly soluble in cold water, which occurs after about 2-3 hours. There is now obtained in almost quantitative yield the ester of the formula wherein n stands for approximately 7 to 9, which still contains an excess of polyethylene glycol monomethyl ether. The ester is purified by dissolving in benzene and being washed several times with a sodium carbonate solution of 5% strength. It is advantageous to agitate all the washing solutions with fresh benzene. In this distribution between benzene and sodium carbonate solution the new ester remains in the benzene, the excess polyethylene glycol monomethyl ether and a small amount of brown impurities are taken up by the dilute soda solution. By evaporating the dried and filtered benzene solution there is obtained the new ester in the form of a colorless to very faintly yellow oil which is easily soluble in most organic solvents with the exception of aliphatic hydrocarbons. The new ester is precipitated from aqueous solutions when heated to about 42°C. but it dissolves again readily on cooling.
Brand name	Tessalon (Forest).
Therapeutic Function	Antitussive
Biological Functions	Benzonatate (TessaIon) is related to the local anesthetic tetracaine. It anesthetizes the stretch receptors in the lungs, thereby reducing coughing.Adverse reactions include hypersensitivity, sedation, dizziness, and nausea.

Benzonatate Preparation Products And Raw materials

Raw materials

1-Bromobutane-->Benzocaine-->Methoxypolyethylene glycols-->NONAETHYLENE GLYCOL MONOMETHYL ETHER-->Ethyl 4-(butylamino)benzoate

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