lymecycline

$0.80 1KG

$1.80 25KG

Min. Order1KG
Purity95%~99.99%
Cas No992-21-2
Supply Ability10 MT/ Month
Update time2021-01-06

Career Henan Chemica Co

4YR

China

Chemical Properties

Product Name	lymecycline
CAS No	992-21-2
EC-No
Min. Order	1KG
Purity	95%~99.99%
Supply Ability	10 MT/ Month
Release date	2021/01/06

Heidi 413

lymecycline Basic information

Product Name:	lymecycline
Synonyms:	N-lysinomethyltetracycline;Armyl;Mucomycin;N6-[[(4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-6-methyl-1,11-dioxonaphthacen-2-yl]carbonylaminomethyl]-L-lysine;Tetralisal;Tetralysal;(+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide;Tertamyl
CAS:	992-21-2
MF:	C29H38N4O10
MW:	602.637
EINECS:	213-592-2
Product Categories:	Antibacterial;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds
Mol File:	992-21-2.mol

lymecycline Chemical Properties

Melting point	192.5°C
Boiling point	648.97°C (rough estimate)
density	1.53
refractive index	1.5500 (estimate)
solubility	Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
pka	2.50±0.24(Predicted)

Safety Information

MSDS Information

lymecycline Usage And Synthesis

Chemical Properties	Yellow, hygroscopic powder.
Originator	Armyl,Armour Pharm.
Uses	Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
Definition	ChEBI: A tetracycline-based broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall.
Manufacturing Process	Amido-N-(lysinomethyl)tetracycline hydrochloride: To 18.3 g of L-lysine hydrochloride dissolved in 100 ml of water is added 10 ml of 37% aqueous solution of formaldehyde. To the resultant mixture is added 44.0 g of anhydrous tetracycline dissolved in 500 ml of tetrahydrofuran. After thorough mixing the product forms over a period of about 15 min as an oily layer which after separation from the aqueous phase is added dropwise to 3 L of stirred isopropyl alcohol. The product after recovery by filtration, is reslurried with acetone, filtered and dried at 65°C at reduced pressure. The product thus obtained has a bioassay of 500 mcg/mg (K. pneumonlae oxytetracyoline assay).
Therapeutic Function	Antibiotic
Pharmaceutical Applications	2-N-lysinomethyl-tetracycline. A water-soluble prodrug of tetracycline available for oral administration. Its antimicrobial activity is due to the tetracycline content. It is lipophilic, rapidly absorbed from the gastrointestinal tract and widely distributed. Concentrations around 1 mg/kg have been found in maxillary sinus tissue some 3 h after administration of a conventional dose. The half-life is 7–14 h. Approximately 30% of an orally administered dose is excreted as active drug in the urine, where it achieves concentrations of 300 mg/L. Its untoward effects and clinical uses are those of tetracycline, although it is claimed to be better tolerated.

lymecycline Preparation Products And Raw materials

Raw materials

L-Lysine hydrochloride-->Tetracycline-->Formaldehyde

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