PBP

$ 8.00 /1KG

Min. Order1KG
Purity99%
Cas No103-16-2
Supply Ability20 Tons
Update time2020-11-16

Longyan Tianhua Biological Technology Co., Ltd

5YR

China

Chemical Properties

Product Name	PBP
CAS No	103-16-2
EC-No	203-083-3
Min. Order	1KG
Purity	99%
Supply Ability	20 Tons
Release date	2020/11/16

PBP Basic information

Abstract Treatment for vitiligo How to use Category Toxic grading Acute toxicity Stimulate data Flammability hazard characteristics Storage Extinguishing agent References

Product Name:	PBP
Synonyms:	MONOBENZONE;PBP;P-BENZYLOXYPHENOL;P-HYDROXYPHENYL BENZYL ETHER;HYDROQUINONE MONOBENZYL ETHER;Benzyl hydroquinone;BENZYL P-HYDROXYPHENYL ETHER;4-BENZYLOXYPHENOL
CAS:	103-16-2
MF:	C13H12O2
MW:	200.23318
EINECS:	203-083-3
Product Categories:	API intermediates;Bifunctional Compounds (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;treat Vitiligo;whiten agent;cosmetics;B;Bioactive Small Molecules;Building Blocks;C9 to C20+;Cell Biology;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Phenols;API;SANODIN
Mol File:	103-16-2.mol

PBP Chemical Properties

Melting point	119-120 °C(lit.)
Boiling point	297.96°C (rough estimate)
density	1,26 g/cm³
refractive index	1.5906 (estimate)
storage temp.	-20°C
form	Powder, Crystals, and/or Chunks
color	Off-white to beige to brown
Water Solubility	slightly soluble
Merck	14,6248
BRN	1958305
InChIKey	VYQNWZOUAUKGHI-UHFFFAOYSA-N
CAS DataBase Reference	103-16-2(CAS DataBase Reference)
NIST Chemistry Reference	Monobenzone(103-16-2)
EPA Substance Registry System	Phenol, 4-(phenylmethoxy)-(103-16-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36-43
Safety Statements	24/25-26-37
WGK Germany	2
RTECS	SJ7700000
Hazard Note	Irritant
TSCA	Yes
HS Code	29095090
Hazardous Substances Data	103-16-2(Hazardous Substances Data)
Toxicity	LD50 i.p. in mice: >600 mg/kg (Takahashi)

PBP Usage And Synthesis

Abstract	Monobenzone, also called 4-(Benzyloxy)phenol and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH. It is used as a topical drug for medical depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans.
Treatment for vitiligo	Monobenzone may cause destruction of melanocytes and permanent depigmentation.Hyperpigmented skin appears to fade more rapidly than does normal skin, and exposure to sunlight reduces the depigmenting effect of the drug. The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes.This function enables it treat the uneven appearance of the skin due to a loss of skin color (vitiligo). It works by permanently removing color from normal skin located around skin with vitiligo. This will help to make the appearance of the skin more even. What calls for special attention is that: Do not use this drug to treat other skin discoloration problems ("sun spots," "age spots," freckles, skin discoloration caused by hormone medicine, perfumes, pregnancy, or skin trauma). Monobenzone is not a mild cosmetic bleach. Because it causes a permanent discoloration of the skin, it may not be the right treatment for these other skin conditions. Besides, Monobenzone is also being considered for the treatment of Melanoma.
How to use	This medication is for use on the skin only. Apply a thin layer of the medication to normal-colored skin, usually 2-3 times daily or as directed by your doctor. Avoid getting this product in your eyes or on the inside of your nose or mouth. If you do get this medication in those areas, flush with plenty of water.After using this medication, the skin will be permanently affected and sensitive to sunlight. Avoid prolonged exposure to sunlight, tanning booths, and sunlamps. Always use a sunscreen of SPF 15 or greater, and wear protective clothing when outdoors.It may take up to 4 months before the full benefit of this drug takes effect. Once the desired skin color is achieved, this medication is applied only as needed to maintain your new skin color (usually 2 times a week).Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.Inform your doctor if your condition persists or worsens after 4 months. You should not use this medication if you are allergic to monobenzone. Do not use monobenzone on any areas that are not affected by vitiligo.
Category	Toxic substance
Toxic grading	Moderate toxicity
Acute toxicity	Abdomen-rat LD50: 4500 mg/kg
Stimulate data	Skin-guinea pigs 5%/48 hours, mild grade.
Flammability hazard characteristics	The drug is combustible, and combustion releases stimulus smoke.
Storage	Ventilated warehouse, low temperature, dry; Separated from food raw materials.
Extinguishing agent	Dry powder, foam, sand, carbon dioxide, mist water.