Firocoxib

$ 40.00 /1Kg/Bag

Min. Order1Kg/Bag
Purity99%
Cas No189954-96-9
Supply Ability1000KG
Update time2021-03-19

Hebei Lihe Biotechnology Co.,ltd

5YR

China

Chemical Properties

Product Name	Firocoxib
CAS No	189954-96-9
EC-No	200-001-2
Min. Order	1Kg/Bag
Purity	99%
Supply Ability	1000KG
Release date	2021/03/19

Firocoxib

Common Name	Firocoxib
CAS Number	189954-96-9	Molecular Weight	336.403
Density	1.3±0.1 g/cm3	Boiling Point	563.9±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₀O₅S	Melting Point	78-80°C
MSDS	N/A	Flash Point	294.8±30.1 °C

Use of Firocoxib

Firocoxib(ML 1785713) is a potent and selective cyclooxygenase (COX)-2 inhibitor with IC50 of 0.13 uM, 58 fold sensitivity for COX2 VSCOX1.IC50 value: 0.13 uM [1]Target: COX2 inhibitorin vitro: Blood concentrations resulting in 50% inhibition of COX-1 and COX-2 activity in vitro were 75 +/- 2 microM and 0.13 +/- 0.03 microM, respectively, and selectivity for inhibiting COX-2 relative to COX-1 was 58. Firocoxib had moderate to high oral bioavailability (54% to 70%), low plasma clearance (4.7 to 5.8 mL/min/kg), and an elimination half-life of 8.7 to 12.2 hours [1]. in vivo: Administration of firocoxib did not cause any adverse effects on GI, or hematological or serum biochemical variables and appears to have been well tolerated by dogs [2]. Firocoxib (0.5 mg/kg) was initially administered i.v. to calves, and following a 14-day washout period, animals received firocoxib orally prior to cautery dehorning. Firocoxib concentrations were determined by liquid chromatography-tandem mass spectrometry [3]. Firocoxib 5 mg/kg was given orally once daily for 180 days to five dogs with clinical signs and histopathological lesions consistent with solar dermatitis/actinic keratosis. On days 0, 50 and 180, the severity of erythema, skin shine, induration and the number of comedones were evaluated by a clinical scoring system [4].
Packaging and shipping

Packaging Detail	0.5kgs/Al-foil bag 1.0kgs/Al-foil bag 2.0kgs/Al-foil bag 5.0 kgs/Al-foil bag 25.0 kgs/drum or upon customers' request.
Storage	Store in a well-closed container away from moisture
Shelf Life	2 years if sealed and store away from direct sun light.
Delivery Detail	within 3 days after get the payment

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