| Name | 10β,17β-dihydroxyestra-1,4-dien-3-one |
| Description | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-selective prodrug of 17β-estradiol, which has neuroprotective effects, improves cognitive dysfunction, and can be used to study brain damage. |
| In vivo | The effect of 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) on PR expression has also been evaluated on animals. PR expression in brains taken from morphine-treated rats manifested the same response to 10β,17β-dihydroxyestra-1,4-dien-3-one or EE as in OVX rats not treated with morphine. These animals were treated with the test compounds (10β,17β-dihydroxyestra-1,4-dien-3-one 30 and 100μg/kg, EE 200μg/kg, and vehicle) via oral gavage twice per day. As indicated by optical density on film exposures, that induction of the highly estrogen-responsive gene was three fold higher in the 10β,17β-dihydroxyestra-1,4-dien-3-one - and EE-treated groups than in the vehicle-treated animals. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (277.41 mM), Sonication is recommended.
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| Keywords | EstrogenReceptor | Estrogen Receptor/ERR | Estrogen Receptor | ERR | 10β,17β-dihydroxyestra-1,4-dien-3-one | 10β,17βdihydroxyestra1,4dien3one | 10β,17β dihydroxyestra 1,4 dien 3 one | 10beta,17beta-dihydroxyestra-1,4-dien-3-one | 10b,17b-dihydroxyestra-1,4-dien-3-one |
| Inhibitors Related | Kaempferol | Tamoxifen | Estradiol | Estradiol benzoate | ARV-471 | Octinoxate | Genistin | Cholesterol | Estriol | Chrysin | Ethisterone | Estrone |
United States
