1-Naphthaleneacetic acid NEW

• MOLECULAR FORMULA :

• C12-H10-O2

• MOLECULAR WEIGHT :

• 186.22

• WISWESSER LINE NOTATION :

• L66J B1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• Standard Draize test

• ROUTE OF EXPOSURE :

• Administration into the eye

• SPECIES OBSERVED :

• Rodent - rabbit

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 1 gm/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LC50 - Lethal concentration, 50 percent kill

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• >207 gm/m3

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 100 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 743 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 609 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 733 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• >5 gm/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 27 gm/kg/90D-C

• TOXIC EFFECTS :

• Behavioral - food intake (animal) Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 30 gm/kg/30D-I

• TOXIC EFFECTS :

• Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

• TYPE OF TEST :

• Mutation test systems - not otherwise specified

• TEST SYSTEM :

• Human Leukocyte

• DOSE/DURATION :

• 100 nmol/L

• REFERENCE :

• EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,29,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80317 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 605 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80317 No. of Facilities: 287 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3732 (estimated) No. of Female Employees: 574 (estimated)