1. Materials information
Names
Name | 1-methyl-7H-xanthine |
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Synonym | More Synonyms |
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1-Methylxanthine Biological Activity
Description | 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP)[1]. 1-Methylxanthine enhances the radiosensitivity of tumor cells[2]. |
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Related Catalog | Research Areas >> Cancer |
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Target | Human Endogenous Metabolite |
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In Vitro | 1-Methylxanthine (1-MTX; 3 mM; for 30 min) increases the radiation-induced clonogenic and apoptotic cell (RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53)) death[2]. 1-Methylxanthine (1MX) exhibits similar activities to other naturally occurring methylxanthines. Unlike caffeine, TP, and theobromine, 3-Methylxanthine (3MX) and 1-methylxanthine do not occur naturally at high levels in plants[1]. |
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References | [1]. Algharrawi KH, et al. Direct conversion of theophylline to 3-methylxanthine by metabolically engineered E. coli. Microb Cell Fact. 2015 Dec 21;14:203. [2]. Youn H, et al. 1-Methylxanthine enhances the radiosensitivity of tumor cells. Int J Radiat Biol. 2009 Feb;85(2):167-74. |
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Chemical & Physical Properties
Density | 1.5±0.1 g/cm3 |
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Melting Point | ≥300 °C |
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Molecular Formula | C6H6N4O2 |
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Molecular Weight | 166.137 |
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Exact Mass | 166.049072 |
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PSA | 83.54000 |
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LogP | -1.52 |
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Index of Refraction | 1.627 |
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Storage condition | -20°C Freezer |
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MSDS
1-Methylxanthine MSDS(Chinese) |
Toxicological Information
CHEMICAL IDENTIFICATIONCHEMICAL NAME : Xanthine, 1-methyl-
CAS REGISTRY NUMBER : 6136-37-4
MOLECULAR FORMULA : C6-H6-N4-O2
HEALTH HAZARD DATAACUTE TOXICITY DATAROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 24,393,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5255 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)
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Safety Information
Hazard Codes | T+ |
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Risk Phrases | R26/27/28 |
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Safety Phrases | S22-S24/25 |
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WGK Germany | 3 |
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RTECS | ZD8575000 |
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HS Code | 2933990090 |
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Precursor & DownStream
Precursor 10 | Previous 1/3 Next |
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CAS#:21236-97-5 6-Amino-3-methy... CAS#:85357-27-3 5,6-diamino-2-m... CAS#:77287-34-4 (Z)-Methanimidi... CAS#:61033-04-3 6-amino-5-nitro...
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DownStream 8 | Previous 1/2 Next |
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CAS#:2757-83-7 2,4,5,6(1H,3H)-... CAS#:57-13-6 Urea CAS#:58-55-9 Theophylline CAS#:58-08-2 Caffeine
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Customs
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
methyl xanthine |
6-Hydroxy-3-methyl-3,9-dihydro-2H-purin-2-one |
1-Methyl-3,7-dihydro-1H-purine-2,6-dione |
methylxanthine |
1H-Purine-2,6-dione, 3,7-dihydromethyl- |
3-Methyl-3,7-dihydro-1H-purine-2,6-dione |
1H-Purine-2,6-dione, 3,7-dihydro-1-methyl- |
1-Methylxanthine |
1-methyl-7H-xanthine |
MFCD00005561 |
1-Methyl Xanthine |
1-methyl-3,7-dihydropurine-2,6-dione |
EINECS 228-108-5 |
3-Methylxanthine |
1H-Purine-2,6-dione, 3,7-dihydro-3-methyl- |
2H-Purin-2-one, 3,9-dihydro-6-hydroxy-3-methyl- |
oxoguanine |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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