1. Materials information
Names
Name | octan-1-ol |
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Synonym | More Synonyms |
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1-Octanol Biological Activity
Description | 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like properties[2]. |
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Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Metabolic Disease Research Areas >> Neurological Disease |
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Target | T-type calcium channel:4 μM (IC50) Human Endogenous Metabolite |
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In Vitro | 1-octanol inhibits native T-currents at subanesthetic concentrations with an IC50 of approximately 4 μM. In contrast, 1-octanol is up to 30-fold less potent in inhibiting recombinant CaV3.3 T-channels heterologously expressed in human embryonic kidney cells[1]. |
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References | [1]. Joksovic PM, et al. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan;77(1):87-94. [2]. Akhtar MK, et al. Microbial production of 1-octanol: A naturally excreted biofuel with diesel-like properties. Metab Eng Commun. 2014 Nov 13;2:1-5. |
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Chemical & Physical Properties
Density | 0.827 g/mL at 25 °C(lit.) |
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Boiling Point | 196 °C(lit.) |
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Melting Point | −15 °C(lit.) |
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Molecular Formula | C8H18O |
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Molecular Weight | 130.22800 |
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Flash Point | 178 °F |
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Exact Mass | 130.13600 |
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PSA | 20.23000 |
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LogP | 2.33920 |
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Vapour density | 4.5 (vs air) |
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Vapour Pressure | 0.14 mm Hg ( 25 °C) |
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Index of Refraction | n20/D 1.429(lit.) |
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Stability | Stable. Flammable. Incompatible with strong oxidizing agents. |
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Water Solubility | insoluble |
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. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Suitable for goods over 50kg
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Delivery: 2-45 days
Cost: low cost
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