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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Basic information
Product Name: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
Synonyms: 2-Acetyl-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;5-Fluoro-2-hydroxyphenyl(methyl) ketone;5'-Fluoro-2'-hydroxyacetophenone,97%;JRH-01009, 1-(5-Fluoro-2-hydroxyphenyl)ethanone, 97%;5’-fluoro-2’-hydroxy-acetophenon;Ethanone, 1-(5-fluoro-2-hydroxyphenyl)-;5'-FLUORO-2'-HYDROXYACETOPHENONE
CAS: 394-32-1
MF: C8H7FO2
MW: 154.14
EINECS: 206-893-5
Product Categories: Aryl Fluorinated Building Blocks;Building Blocks;C7 to C8;C7-C8;Chemical Synthesis;Fluorinated Building Blocks;Adehydes, Acetals & Ketones;Fluorine Compounds;Phenols;C7 to C8;Acetophenone series;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Alcohols and Derivatives;Carbonyl Compounds;Aromatic Acetophenones & Derivatives (substituted);ketone;(intermediate of nebivolol);Benzenes;Carbonyl Compounds;Ketones;1
Mol File: 394-32-1.mol
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Structure
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties
Melting point 56-58 °C(lit.)
Boiling point 65-66 °C8 mm Hg(lit.)
density 1.1850 (estimate)
Fp 65-66°C/8mm
storage temp. Inert atmosphere,Room Temperature
form powder to crystal
pka 10.17±0.18(Predicted)
color White to Gray to Brown
Water Solubility Soluble 0.68 G/L
BRN 2359087
CAS DataBase Reference 394-32-1(CAS DataBase Reference)
NIST Chemistry Reference 5-Fluoro-2-hydroxyacetophenone(394-32-1)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-37/39-36/37/39
WGK Germany 3
RTECS AM8502300
HazardClass IRRITANT
HS Code 29147000
MSDS Information
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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone English
ACROS English
SigmaAldrich English
ALFA English
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Usage And Synthesis
Chemical Properties light yellow to beige-brown crystals or
Uses 5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:
1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
3-hydroxy and 3-methoxyflavones
3-hydroxy and 3-methoxy 2-styrylchromones
Definition ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.
Preparation Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).
China
