1 - [(2S) - 2-pyrrolidine carbonyl] - pyrrolidine

‌Product Name‌: N-Despropyl (R)-Ropivacaine
‌CAS No.‌: 27262-43-7
‌Molecular Formula‌: C₁₄H₂₀N₂O
‌Molecular Weight‌: 232.32

🌟 ‌Product Overview‌

‌Brief Introduction‌: N-Despropyl (R)-Ropivacaine is a high-purity chiral intermediate and impurity reference standard critical for the synthesis and quality control of ‌Ropivacaine‌, a widely used long-acting local anesthetic‌12. Its stereochemical specificity ensures accurate analytical and manufacturing applications in pharmaceutical development‌34.
‌Primary Function‌: Key impurity standard for Ropivacaine validation; intermediate in API synthesis‌12.
‌Applicable Fields‌: Pharmaceutical manufacturing, analytical chemistry, and regulatory compliance‌12.

✅ ‌Key Advantages‌

🟡 ‌≥98% Purity‌: Verified by HPLC, NMR, and GC for analytical precision‌12.
🟡 ‌Chiral Specificity‌: (R)-isomer ensures compatibility with enantioselective synthesis‌34.
🟡 ‌Scalable Supply‌: Available from 1g to 25kg with custom packaging options‌12.

📌 ‌Application Scenarios‌

1. ‌Ropivacaine Quality Control‌: Essential impurity reference for drug batch validation‌12.

2. ‌API Synthesis‌: Intermediate in the production of enantiomerically pure local anesthetics‌34.

3. ‌Regulatory Compliance‌: Supports pharmacopeial testing (USP/EP) and GMP protocols‌12.

🔬 ‌Quality Certifications‌

• ‌Testing Standards‌: Complies with USP/EP guidelines; validated by HPLC (>98%), NMR, and mass spectrometry‌12.

• ‌Physical Properties‌: Melting point 129-130°C, stable under inert gas storage‌36.

📈 ‌Market Trends‌

The demand for N-Despropyl (R)-Ropivacaine is driven by the expanding use of ‌Ropivacaine‌ in surgical and pain management applications. With global pharmaceutical regulations emphasizing impurity profiling, this reference standard is projected to grow steadily, particularly in Asia-Pacific markets‌12.