1. Materials information
Names
| Name | 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine |
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| Synonym | More Synonyms |
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GBR 12935 Biological Activity
| Description | GBR 12935 is a potent, and selective dopamine reuptake inhibitor.IC50 value: Target: dopamine reuptake inhibitorin vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6. The binding of [3H]GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine) [1]. Co-perfusion of 100 microM GBR 12909 or GBR 12935 with either 100 microM sulpiride or raclopride produced a significant reduction in the GBR 12909 or GBR 12935 induced increase in the extracellular levels of dopamine to basal levels. In vitro, GBR 12909 (1-9 nM) dose-dependently inhibited active uptake of [3H]dopamine in homogenates of the nucleus accumbens [2].in vivo: GBR 12935 elevated locomotion to a greater extent in C57BL/6J mice at the maximally active dose of 10 mg/kg. Locomotor stimulation by GBR 12935 remained consistent in both strains with repeated injections. DBA/2J mice became sensitized to cocaine-induced stereotypy with repeated injections. Cocaine induced no stereotypy in C57BL/6J mice on any test day. No stereotypies were induced by GBR 12935 in either strain on any test day [3]. |
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| Related Catalog | Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease |
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| References | [1]. Hiroi T, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9. [2]. Rahman S, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44. [3]. Tolliver BK, et al. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9. |
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Chemical & Physical Properties
| Density | 1.067g/cm3 |
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| Boiling Point | 540.6ºC at 760 mmHg |
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| Molecular Formula | C28H34N2O |
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| Molecular Weight | 414.58 |
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| Flash Point | 143.9ºC |
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| PSA | 90.31000 |
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| LogP | 4.63060 |
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| Index of Refraction | 1.576 |
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| Storage condition | 2-8℃ |
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Customs
| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2Z)-but-2-enedioate (1:1) |
| Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, (2Z)-2-butenedioate (1:1) |
| 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2Z)-2-butenedioate (1:1) |
| 1-(2-benzhydryloxy-ethyl)-4-(3-phenyl-propyl)-piperazine |
| Piperazine,1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl) |
| N-[3-tert-Butyl-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N-[4-[2-(4-Morpholinyl)ethoxy]naphthalen-1-yl]urea |
| 1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine |
| 1-(2-(diphenylmethoxy)-ethyl)-4-(3-phenylpropyl)piperazine |
| 1-(2-(Benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine maleate |
| GBR 12935 |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
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Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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