1. Materials information
Names
| Name | Methyl 4-Bromobutyrate |
|---|
| Synonym | More Synonyms |
|---|
Br-C3-methyl ester Biological Activity
| Description | Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1]. |
|---|
| Related Catalog | Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker |
|---|
| Target | Alkyl/ether |
|---|
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
|---|
| References | [1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377. |
|---|
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|
| Boiling Point | 186.5±0.0 °C at 760 mmHg |
|---|
| Molecular Formula | C5H9BrO2 |
|---|
| Molecular Weight | 181.028 |
|---|
| Flash Point | 87.0±13.0 °C |
|---|
| Exact Mass | 179.978592 |
|---|
| PSA | 26.30000 |
|---|
| LogP | 1.47 |
|---|
| Vapour Pressure | 0.7±0.3 mmHg at 25°C |
|---|
| Index of Refraction | 1.456 |
|---|
| Storage condition | Room temperature. |
|---|
| Water Solubility | insoluble |
|---|
MSDS
Br-C3-methyl ester MSDS(Chinese) |
Safety Information
| Hazard Codes | Xn:Harmful; |
|---|
| Risk Phrases | R22;R36/37/38 |
|---|
| Safety Phrases | S37/39-S26 |
|---|
| HS Code | 2915900090 |
|---|
Precursor & DownStream
| Precursor 0 |
|
|---|
| DownStream 9 | Previous 1/3 Next |
|---|
 CAS#:107903-02-6
methyl 4-aminoo...
 CAS#:111479-52-8
dimethyl 2-(ben...
 CAS#:33036-62-3
4-Bromo-1-butanol
 CAS#:71-36-3
Butanol
|
Customs
| HS Code | 2915900090 |
|---|
| Summary | 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0% |
|---|
Synonyms
| Butanoic acid, 4-bromo-, methyl ester |
| MFCD00041482 |
| Butyric acid, 4-bromo-, methyl ester |
| EINECS 225-523-3 |
| 4-Bromobutyric Acid Methyl Ester |
| Methyl 4-bromobutanoate |
| Methyl 4-bromobutyrate |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
Email address: sun@fdachem.com
Mob: 86 13526505137
WhatsApp/Skype/Wechat/LINE: 8613526505137
China
