1. Materials information
Names
| Name | (-)-menthol |
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| Synonym | More Synonyms |
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L-Menthol Biological Activity
| Description | (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1]. |
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| Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer |
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| Target | TRPM8[1] |
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| In Vitro | (-)-Menthol (Menthol ) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish[1]. (-)-Menthol (0.8 mM) can increase [Ca2+]i via transmembrane influx or store release pathways. Peak increase in [Ca2+]i was 102.3±39 nM (n=3) in (-)-Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25(OH)2D3 with (-)-Menthol, respectively[1]. Combination of 1α,25(OH)2D3 with (-)-Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression[1]. |
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| References | [1]. Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44(2):125-30. |
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Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
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| Boiling Point | 215.4±8.0 °C at 760 mmHg |
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| Melting Point | 41-43ºC |
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| Molecular Formula | C10H20O |
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| Molecular Weight | 156.265 |
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| Flash Point | 93.3±0.0 °C |
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| Exact Mass | 156.151413 |
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| PSA | 20.23000 |
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| LogP | 3.20 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.457 |
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| Water Solubility | insoluble |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Suitable for goods over 50kg
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Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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