(-)-Huperzine A NEW

Huperdine A is a natural alkaloid extracted from Melaleuca SPP. It is a potent, reversible and highly selective second-generation acetylcholinesterase inhibitor. It is a yellowish to white crystalline powder, soluble in chloroform, soluble in methanol, ethanol and slightly soluble in water. It has high lipid solubility, small molecule and can well permeate the blood-brain barrier. After entering the center, it distributes in the frontal lobe, temporal lobe, hippocampus and other brain regions closely related to learning and memory. At low dose, it has a strong inhibitory effect on AchE, which significantly increases the content of Ach in the synaptic gap in the distribution area, thus enhancing neuronal excitation conduction and enhancing the excitatory effect in the brain regions of learning and memory. It can improve cognitive function, enhance memory retention and promote memory reproduction. It is currently the most successful drug for the treatment of Alzheimer's disease (senile dementia) in China.

Huperzine A not only inhibits cholinesterase activity, but also affects the free radical system, reduces somatostatin, intracellular [Ca2+], glutamate content, and increases calmodulin (CaM) and calmodulin messenger RNA (CaMmRNA) expression levels and other pharmacological mechanisms to improve cognitive function and learning and memory ability.

Huperzine A is a reversible and potent cholinesterase inhibitor, which is stronger than physostigmine, neostigmine and Tacrine. For myasthenia gravis, the effective rate is 99%. Clinical trials show that this product is suitable for benign memory disorders, can improve the patients' ability of pointing memory, associative learning, image recall, meaningless figure recognition and portrait recall, and can also enhance the learning and memory of normal people. This product can also improve the memory disorders caused by dementia patients and organic brain lesions. Huperzine A can be used clinically to treat the following symptoms:

1, for the treatment and improvement of middle-aged and elderly memory function decline, improve associative recall function; For memory decline caused by excessive use of the brain, improve learning and work efficiency;

2, for neurasthenia associated with memory decline;

3, huperzine A is used for memory loss caused by cerebrovascular disorders;

4, used to improve the memory of Alzheimer's disease, improve and restore patients' cognition, memory function and improve emotional behavior abnormalities have obvious efficacy;

5, used to treat myasthenia gravis;

6. Huperzine A can improve association disorder, low cognitive function and memory loss associated with schizophrenia.

7, it can improve the memory function decline associated with a variety of brain diseases and physical diseases.

Side effect

Skin hives, abdominal pain, salivation, muscle twitching, diarrhea, and insomnia are uncommon.

When the dose is too large, it can cause dizziness, nausea, gastrointestinal discomfort, chest tightness, fatigue, bradycardia and other reactions, which can generally disappear on their own, and can be alleviated and disappeared when the reaction is obvious.