| Name | β-Glucuronidase-IN-1 |
| Description | β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase. |
| In vitro | β-Glucuronidase-IN-1 (0.01-100 μM) inhibits E. coli β-glucuronidase activity in a dose-dependent manner(IC50 and Ki of 283 nM and 164 nM, respectively).[1]
β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells with EC50 of 17.7 nM.[1] |
| In vivo | β-Glucuronidase-IN-1 (10 μg; oral gavage; twice per day; 11 days) shields the gastrointestinal epithelium of mice from damage induced by CPT-11, preserving the glandular structure in the treated intestinal tissues.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.7 mM), Sonication is recommended.
DMSO : 30 mg/mL (70.5 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | β-Glucuronidase-IN-1 | βGlucuronidaseIN1 | β-glucuronidase | β Glucuronidase IN 1 | E. coli β-glucuronidase | b-Glucuronidase-IN-1 | beta-Glucuronidase-IN-1 | Bacterial |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | Urethane | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Isoeugenol | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Anti-Bacterial Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
