Basic information Safety Related Supplier

ChemicalBook Product Catalog (±)-Fabesetron hydrochloride

1/1

(±)-Fabesetron hydrochloride NEW

$1970.00 25mg

$2580.00 50mg

$3400.00 100mg

Min. Order
Purity
Cas No129299-81-6
Supply Ability10g
Update time2025-07-21

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

show more

Enterprise Verified

Business Bank account Basic Contact Infomation Business Address Trade Company

Chemical Properties

Product Name	(±)-Fabesetron hydrochloride
CAS No	129299-81-6
EC-No
Min. Order
Purity
Supply Ability	10g
Release date	2025/07/21

Product Introduction

Bioactivity

Name	(±)-Fabesetron hydrochloride
Description	FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.
In vivo	FK1052 (1 mg/kg i.v. ×4) apparently reduces delayed emesis caused by Methotrexate (MTX) and increases, but not significantly, the time for onset of emesis.?Furthermore, increasing the dose to 3.2 mg/kg of FK1052 also significantly inhibits the number of the emetic episodes induced by MTX, of which the action is more effective than the treatment with FK1052 at 1 mg/kg.In conscious rats, both 5-HT and 5-methoxytryptamine significantly increase fecal pellet output and accelerate colonic transit.?In contrast, the effect of 2-methyl-5-HT is slight.?Although Ondansetron and Granisetron slightly reduce 5-HT (1 mg/kg s.c.) stimulated colonic transit, FK1052, at 0.1 mg/kg p.o., inhibits completely the increases in the colonic transit.?Furthermore, FK1052, Ondansetron and Granisetron significantly depress the increase in fecal pellet output caused by wrap-restraint stress, with ED50 values of 0.21, 3.0 and 1.1 mg/kg p.o., respectively.?Intraperitoneal administration of 5-HT and 5-methoxytryptamine, but not 2-methyl-5-HT, produces a dose-related increase in the incidence of diarrhea in fasted mice.?5-HT (0.32 mg/kg i.p.)-induced diarrhea is also inhibited by FK1052, Ondansetron and Granisetron, with ED50 values of 0.09, 2.3 and 0.88 mg/kg p.o., respectively.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Keywords	FK-1052 Hydrochloride \| FK1052 Hydrochloride \| FK 1052 Hydrochloride \| Fabesetron Hydrochloride \| 5HTReceptor \| 5-HT3 Receptor \| 5HT Receptor \| (±)Fabesetron hydrochloride \| (±) Fabesetron hydrochloride
Inhibitors Related	Serotonin hydrochloride \| Alverine citrate \| Olanzapine \| Dapoxetine hydrochloride \| Clozapine N-Oxide \| Mirtazapine \| Amitriptyline hydrochloride \| Cloperastine hydrochloride \| Trazodone hydrochloride \| Mianserin hydrochloride \| Fluoxetine hydrochloride \| Cinchonidine

show more

Company Profile Introduction

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book