| 名称 | (-)-Epigallocatechin Gallate |
| 描述 | (-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells. |
| 细胞实验 | LoVo, SW480, HCT-8, and HT-29 cells are seeded in 96-well plates at a concentration of 5×103?cells; each cell line is totally seeded in the 12 wells. Complete medium is added to the wells, up to 200 μL; the medium contains 0 μg/mL, 10 μg/mL, 20 μg/mL, and 35 μg/mL of epigallocatechol gallate. The inhibition rate=[1 - (absorbance of Epigallocatechol Gallate group - absorbance of control group)/(absorbance of control group - absorbance of blank control group)] × 100. |
| 体外活性 | METHODS: Human thyroid cancer cells TT, TPC-1 and ARO were treated with (-)-Epigallocatechin Gallate (10-200 µM) for 24 h. Cell viability was detected using MTS assay. |
| 体内活性 | METHODS: To investigate the protective effect against acute injury, (-)-Epigallocatechin Gallate (200 mg/kg) was administered to ICR mice by gavage once a day for one week, followed by intraperitoneal injection of LPS (15 mg/kg) to induce acute injury.
RESULTS: (-)-Epigallocatechin Gallate protects mice from LPS-induced acute stress, while stabilizing gut microorganisms, improving sphingolipid metabolism, and inhibiting harmful metabolite levels. [3] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (218.16 mM)
H2O : 50 mg/mL (109.08 mM), Sonication is recommended.
Ethanol : 45.8 mg/mL (100 mM)
|
| 关键字 | ( ) Epigallocatechin Gallate | Epigallocatechin Gallate | inhibit | FB-2 cells | Inhibitor | colorectal cancer | LPS-induced bone resorption | Endogenous Metabolite | cell proliferation. | Thyroid cancer | ()Epigallocatechin Gallate |
| 相关产品 | Sucrose | Emtricitabine | Glycerol | Thymidine |
| 相关库 | 抗癌天然产物库 | 风味化合物库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | 天然产物库 | 抗寄生虫天然产物库 | 抗衰老化合物库 | 抗病毒中药单体化合物库 | 药食同源库 |
United States
