DL-Selenomethionine NEW

• MOLECULAR FORMULA :

• C5-H11-N-O2-Se

• MOLECULAR WEIGHT :

• 196.13

• WISWESSER LINE NOTATION :

• QVYZ2-SE-1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 11 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 22 mg/kg

• TOXIC EFFECTS :

• Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Cardiac - other changes Lungs, Thorax, or Respiration - other changes

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intracervical

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 13 mg/kg

• TOXIC EFFECTS :

• Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Mammal - pig

• DOSE/DURATION :

• 7450 ug/kg

• TOXIC EFFECTS :

• Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Bird - duck

• DOSE/DURATION :

• 37 mg/kg/12W-C

• TOXIC EFFECTS :

• Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 14710 mg/kg

• SEX/DURATION :

• female 8 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

• TYPE OF TEST :

• Cytogenetic analysis

• TEST SYSTEM :

• Human Lymphocyte

• DOSE/DURATION :

• 80 umol/L

• REFERENCE :

• MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,503,1989 *** REVIEWS *** ACGIH TLV-TWA 0.2 mg(Se)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.2 mg(Se)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,224,1971 OSHA PEL (Gen Indu):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV