Name | β,β-Dimethylacrylshikonin |
Description | 1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
Solubility Information | DMSO : 3.70 mg/mL (9.99 mM), Sonication is recommended.
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Keywords | β,β-Dimethylacrylshikonin | β,βDimethylacrylshikonin | β,β Dimethylacrylshikonin | Isoarnebin I | Inhibitor | inhibit | HIFProlylHydroxylase | HIF-1α | HIF/HIFProlylHydroxylase | HIF/HIF ProlylHydroxylase | HIF Prolyl-Hydroxylase | HIF ProlylHydroxylase | HIF | ERK | beta,beta-Dimethylacrylshikonin | beta, beta-Dimethylacrylshikonin | b,b-Dimethylacrylshikonin | b, b-Dimethylacrylshikonin |
Inhibitors Related | TBHQ | Deferoxamine Mesylate | Lidocaine | Astragaloside IV | Glucosamine | Hydroxycitric acid tripotassium hydrate | Lidocaine hydrochloride | Tauroursodeoxycholate | Chloramphenicol | Nisin Z | Albendazole | Glucosamine sulfate |
Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library |