1. Materials information
Names
| Name | digitoxin |
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| Synonym | More Synonyms |
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Digitoxin Biological Activity
| Description | Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 value of Digitoxin is 0.78 μM.IC50 value: 0.78 μM (EC50)Target: Na+/K+-ATPasein vitro: Digitoxin shows a significantly cytotoxic effect in H1975 cells by causing G2 phase arrest, also remarkably activates 5' adenosine monophosphate-activated protein kinase (AMPK). Moreover, Digitoxin suppresses microtubule formation through decreasing α-tubulin. Digitoxin effectively depresses the growth of TKI-resistance NSCLC H1975 cells by inhibiting microtubule polymerization and inducing cell cycle arrest. Digitoxin has the highest cytotoxicity in H1975 cells, whose CC50 value was 0.19 ± 0.06 μM. Digitoxin-induced inhibition mechanism is likely due to causing G2/M cell cycle arrest in H1975 cells in dose dependent manners. |
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| Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Na+/K+ ATPase Natural Products >> Steroids Research Areas >> Cardiovascular Disease |
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| References | [1]. Zhang YZ, et al. Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation. Molecules. 2016 |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 902.3±65.0 °C at 760 mmHg |
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| Melting Point | 240ºC (dec.)(lit.) |
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| Molecular Formula | C41H64O13 |
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| Molecular Weight | 764.939 |
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| Flash Point | 269.5±27.8 °C |
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| Exact Mass | 764.434692 |
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| PSA | 182.83000 |
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| LogP | 2.44 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.594 |
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. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Suitable for goods over 50kg
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Delivery: 2-45 days
Cost: low cost
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