1. Materials information
Names
| Name | (+)-Cloprostenol isopropyl ester |
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| Synonym | More Synonyms |
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Cloprostenol isopropyl ester Biological Activity
| Description | Cloprostenol isopropyl ester, a prostaglandin F2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a Ki value of 28 nM[1][2]. |
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| Related Catalog | Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor |
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| In Vivo | Cloprostenol isopropyl ester (25 μg/kg; i.p.; daily, for 4 weeks; male mice) induces changes in the evolution of the spermatogenesis and spermiogenesis[1]. Cloprostenol isopropyl ester (1 μg, 30 μL; injected into the eye; for 2, 4 and 6 h) causes pupil constriction in the cat. Cloprostenol isopropyl ester has an efficacious ocular hypotensive in the lasered monkey[2]. Animal Model: Male mice (50–80 days)[1] Dosage: 25 μg/kg Administration: Intraperitoneal injection; daily, for 4 weeks Result: Stimulated the androgen synthesis in a time-dependent manner. |
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| References | [1]. Sava A, et, al. Electron microscopic aspects of the effects of certain prostaglandin analogs on mouse testes. Rom J Morphol Embryol. 2015;56(2 Suppl):771-5. [2]. Hellberg MR, et, al. Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S13-33. |
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Chemical & Physical Properties
| Density | 1.227±0.06 g/cm3 |
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| Molecular Formula | C25H35ClO6 |
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| Molecular Weight | 466.99500 |
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| Exact Mass | 466.21200 |
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| PSA | 96.22000 |
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| LogP | 4.06200 |
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| Water Solubility | Insuluble (4.1E-3 g/L) (25 ºC) |
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Synonyms
| Cloprostenol isopropyl ester |
| CPG 6112-95 |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Cost: low cost
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