1. Materials information
Belvarafenib Biological Activity
| Description | Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. |
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| Related Catalog | Signaling Pathways >> MAPK/ERK Pathway >> Raf Research Areas >> Cancer |
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| Target | BRafV600E:7 nM (IC50) CRAF:5 nM (IC50) B-Raf:56 nM (IC50) |
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| In Vitro | Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1]. |
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| References | [1]. WO 2013/100632 A1. |
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Chemical & Physical Properties
| Molecular Formula | C23H16ClFN6OS |
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| Molecular Weight | 478.93 |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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