1. Materials information
Names
| Name | β-alanine |
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| Synonym | More Synonyms |
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beta-Alanine Biological Activity
| Description | β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer. |
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| Related Catalog | Natural Products >> Others Research Areas >> Metabolic Disease |
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| Target | Human Endogenous Metabolite |
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| In Vitro | Cells treated with β-alanine display significantly suppressed basal and peak ECAR (aerobic glycolysis), with simultaneous increase in glucose transporter 1 (GLUT1). Additionally, cells treated with β-alanine exhibit significantly reduced basal and peak OCR (oxidative metabolism), which is accompanied by reduction in mitochondrial content with subsequent suppression of genes which promote mitochondrial biosynthesis. Suppression of glycolytic and oxidative metabolism by β-alanine results in the reduction of total metabolic rate, although cell viability is not affected.β-alanine is shown to reduce both cell migration and proliferation without acting in a cytotoxic fashion. Moreover, β-alanine significantly increases malignant cell sensitivity to doxorubicin, suggesting a potential role as a co-therapeutic agent[1]. |
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| References | [1]. Vaughan RA, et al. β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer. 2014 Jan 24;13:14. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 237.1±23.0 °C at 760 mmHg |
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| Melting Point | 202 °C (dec.)(lit.) |
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| Molecular Formula | C3H7NO2 |
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| Molecular Weight | 89.093 |
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| Flash Point | 97.2±22.6 °C |
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| Exact Mass | 89.047676 |
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| PSA | 63.32000 |
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| LogP | -0.86 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.463 |
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| Storage condition | Store at RT. |
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| Water Solubility | H2O: 1 M at 20 °C, clear, colorless |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Suitable for goods under 50kg
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Suitable for goods over 50kg
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Cost: high cost
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Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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