ChemicalBook Product Catalog Chemical Reagents Organic reagents The polycyclic compound 2-Hydroxy-1-naphthaldehyde

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2-Hydroxy-1-naphthaldehyde NEW

$0.10 1000KG

$5.00 1KG

Min. Order1KG
Purity99%
Cas No708-06-5
Supply Abilityg-kg-tons, free sample is available
Update time2024-04-16

Henan Fengda Chemical Co., Ltd

2YR

China

Chemical Properties

Product Name	2-Hydroxy-1-naphthaldehyde
CAS No	708-06-5
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons, free sample is available
Release date	2024/04/16

1. Materials information

Name	2-Hydroxy-1-naphthaldehyde
Synonym	More Synonyms

Description	CFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRAS(G12C)
In Vitro	CFL-137 (72 h)H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk 11.4, 24.2, 24.5, 12.3, 43.3, 44.5, 27.63, 32.4, 46.9, 26.2, 25.0, 10.8, 66.2 µM[1]。
In Vivo	CFL-137 (5 mg/kg，；15 mg/kg，；30 mg/kg，；i.p.) H1792 (KRasG12C LCLC-103H (KRasWT) 。 Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1] Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments Administration: I.p. Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 32.5%.
References	[1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.

Density	1.3±0.1 g/cm3
Boiling Point	305.8±0.0 °C at 760 mmHg
Melting Point	82-85ºC
Molecular Formula	C11H8O2
Molecular Weight	172.18
Flash Point	134.3±13.0 °C
Exact Mass	172.052429
PSA	37.30000
LogP	2.84
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.719

2-Hydroxy-naphthaldehyde MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ0300000

CHEMICAL NAME :
1-Naphthaldehyde, 2-hydroxy-

CAS REGISTRY NUMBER :
708-06-5

BEILSTEIN REFERENCE NO. :
0742777

LAST UPDATED :
199709

DATA ITEMS CITED :
5

MOLECULAR FORMULA :
C11-H8-O2

MOLECULAR WEIGHT :
172.19

WISWESSER LINE NOTATION :
T66J BVH CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
710 mg/kg

TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
1170 mg/kg

TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
7250 mg/kg/5D-I

TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
15 gm/kg/30D-I

TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased Blood - change in clotting factors Blood - changes in leukocyte (WBC) count

REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H315-H319-H335-H400
Precautionary Statements	P261-P273-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;N: Dangerous for the environment;
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	UN 3077 9
WGK Germany	2
RTECS	QJ0300000
HS Code	2912499000

Chloroform

67-66-3

2-Naphthol

135-19-3

~77%

2-Hydroxy-napht...

708-06-5

Literature: Kalechits; Osinovskii; Matveenko; Ol'khovik Russian Journal of Applied Chemistry, 2002 , vol. 75, # 6 p. 962 - 964

1-Naphthaleneca...

5392-12-1

~92%

2-Hydroxy-napht...

708-06-5

Literature: Ranade, Anup A.; Joseph, Augustine R.; Kumbhar, Virendra B.; Paradkar, Madhusudan V. Journal of Chemical Research, Miniprint, 2003 , # 8 p. 857 - 868 Title/Abstract Full Text Show Details Ranade, Anup A.; Joseph, Augustine R.; Kumbhar, Virendra B.; Paradkar, Madhusudan V. Journal of Chemical Research, Miniprint, 2003 , # 11 p. 1175 - 1184

N,N-Dimethylfor...

68-12-2

2-Naphthol

135-19-3

~90%

2-Hydroxy-napht...

708-06-5

Literature: Moazzam Ali, Mir; Sana, Sariah; Tasneem; Rajanna; Saiprakash Synthetic Communications, 2002 , vol. 32, # 9 p. 1351 - 1356

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HS Code	2912499000
Summary	2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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2-Hydroxy-1-naphthaldehyde

2-hydroxynaphthalene-1-carboxaldehyde

1-naphthalenecarboxaldehyde, 2-hydroxy

1-Naphthalenecarboxaldehyde, 2-hydroxy-

EINECS 211-902-0

2-Hydroxy-naphthaldehyde

MFCD00004005

.β.-Hydroxy-.α.-naphthaldehyde

2. Packaging of materials

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.