1. Materials information
Names
| Name | 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindole-1,3-dione |
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| Synonym | More Synonyms |
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Thalidomide-5-OH Biological Activity
| Description | Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1]. |
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| Related Catalog | Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase |
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| Target | Cereblon |
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| References | [1]. Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604. |
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Chemical & Physical Properties
| Density | 1.611g/cm3 |
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| Boiling Point | 600ºC at 760mmHg |
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| Molecular Formula | C13H10N2O5 |
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| Molecular Weight | 274.22900 |
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| Flash Point | 316.7ºC |
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| Exact Mass | 274.05900 |
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| PSA | 107.27000 |
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| LogP | 0.00720 |
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| Index of Refraction | 1.679 |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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