ChemicalBook Product Catalog Chemical Reagents Organic reagents Fatty alcohols 1H,1H,7H-DODECAFLUORO-1-HEPTANOL

1/2

1H,1H,7H-DODECAFLUORO-1-HEPTANOL NEW

$1.00 100KG

$5.00 25KG

$6.00 1KG

Min. Order1KG
Purity99%
Cas No335-99-9
Supply Abilityg-kg-tons, free sample is available
Update time2024-03-29

Henan Fengda Chemical Co., Ltd

2YR

China

Chemical Properties

Product Name	1H,1H,7H-DODECAFLUORO-1-HEPTANOL
CAS No	335-99-9
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons, free sample is available
Release date	2024/03/29

1. Product information

Name	[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
Synonym	More Synonyms

Description	Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM).
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Cancer
Target	IC50: 3.4 nM (20S proteasome)[1] Ki: 0.93 nM (20S proteasome)[1]
In Vitro	Ixazomib (MLN2238) is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 value of 3.4 nM (Ki of 0.93 nM). At higher concentrations, Ixazomib (MLN2238) also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites (IC50 of 31 and 3,500 nM, respectively). Cell viability studies are performed in a variety of mammalian cell lines to compare the in vitro antiproliferative effects of Ixazomib (MLN2238) with Bortezomib. Studies performed with A375 (lung), H460 (lung), HCT-116 (colon), and HT-29 (colon) cells revealed similar LD50 values for the two compounds, which range from 4 to 58 nM[1].
In Vivo	Ixazomib (MLN2238) shows antitumor activity in the CWR22 xenograft model. The antitumor effects of Ixazomib (MLN2238) dosed at 14 mg/kg i.v. or 7 mg/kg i.v. are compared with Bortezomib dosed at 0.8 mg/kg i.v. or 0.4 mg/kg i.v. on a twice weekly regimen. The high dose for both Ixazomib (MLN2238) and Bortezomib shows similar antitumor activity in this model (T/C=0.36 and 0.44, respectively). However, Ixazomib (MLN2238) (7 mg/kg) shows greater efficacy at a 0.5 MTD dose compared with a 0.5 MTD dose of Bortezomib (0.4 mg/kg; T/C=0.49 compared with T/C=0.79, respectively) Ixazomib (MLN2238) shows time-dependent reversible proteasome inhibition; however, the proteasome dissociation half-life (t1/2) for Ixazomib (MLN2238) is determined to be 18 minutes[1].
Cell Assay	Calu-6 cells are cultured in MEM containing 10% fetal bovine serum and 1% penicillin/streptomycin and plated 1 d before the start of the experiment at 10,000 cells per well in a 384-well plate. For IC50 determinations, cells are treated with varying concentrations of Bortezomib or Ixazomib in DMSO (0.5% final, v/v) for 1 h at 37°C. For reversibility experiments, cells are treated with either 1 μM Bortezomib or Ixazomib (MLN2238) for 30 min at 37°C and then washed thrice in medium to remove the compounds. Cells are incubated for an additional 4 h at 37°C, after which the medium is removed and replaced with fresh medium. Proteasome activity is assessed by monitoring hydrolysis of the chymotrypsin-like substrate Suc-LLVY-aminoluciferin in the presence of luciferase using the Proteasome-Glo assay reagents. Luminescence is measured using a LEADseeker instrument[1].
Animal Admin	Mice[1] Male CB17-SCID mice, approximately 8 to 11 wk of age, are inoculated s.c. with freshly dissected CWR22 tumor fragments (~20 mg) in the right dorsal flank. Mean tumor volume (MTV) is calculated using the following formula: 0.5×(length×width2). When MTV reaches approximately 150 to 200 mm3, animals are randomized into treatment groups (n=10 per group) before dosing. Antitumor activity is determined at the end of the study by calculating the treatment over control (T/C) ratio of their MTVs at the end of the study. Rats[1] To determine the pharmacokinetic profile of Ixazomib and Bortezomib in a second species, Sprague-Dawley rats are administered a single i.v. dose of Ixazomib (MLN2238) at either 0.3 or 0.2 mg/kg or Bortezomib at 0.2 mg/kg. Both Ixazomib doses provided a greater plasma exposure (AUC0-48h of 704 and 1,070 h•ng/mL for 0.2 and 0.3 mg/kg doses, respectively) compared with Bortezomib (AUC0-48h of 206 h•ng/mL), confirming that Ixazomib (MLN2238) also has improved plasma exposure compared with Bortezomib in rodents.
References	[1]. Kupperman E, et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010 Mar 1;70(5):1970-80.

Density	1.3±0.1 g/cm3
Molecular Formula	C₁₄H₁₉BCl₂N₂O₄
Molecular Weight	361.029
Exact Mass	360.081482
PSA	105.64000
LogP	2.82
Index of Refraction	1.546
Storage condition	2-8°C

Name	2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol
Synonym	More Synonyms

Density	1.6±0.1 g/cm3
Boiling Point	163.3±40.0 °C at 760 mmHg
Melting Point	-20°C
Molecular Formula	C₇H₄F₁₂O
Molecular Weight	332.087
Flash Point	52.5±27.3 °C
Exact Mass	332.007050
PSA	20.23000
LogP	3.58
Vapour Pressure	0.7±0.7 mmHg at 25°C
Index of Refraction	1.291

MSDS(Chinese)

Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S37/39-S26
RTECS	MJ4500000
HS Code	2905590090

trimethyl-(1H,1...

CAS#:56002-71-2

2,2,3,3,4,4,5,5...

CAS#:335-99-9

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 17, p. 1699 - 1703 Zhurnal Organicheskoi Khimii, , vol. 17, p. 1903 - 1908

Methanol

CAS#:67-56-1

Tetrafluoroethylene

CAS#:116-14-3

2,2,3,3,4,4,5,5...

CAS#:335-99-9

Literature: Industrial and Engineering Chemistry, , vol. 51, p. 829

bis(2,2,3,3,4,4...

CAS#:85892-57-5

~86%

Benzenesulfonamide

CAS#:98-10-2

2,2,3,3,4,4,5,5...

CAS#:335-99-9

Literature: Markovskii, L. N.; Stukalo, E. A.; Ogloblin, A. N.; Iksanova, S. V. Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 1 p. 65 - 70 Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 1 p. 72 - 79

Precursor 7	Previous 1/2 Next
CAS#:78491-64-2 tetrakis((2,2,3... CAS#:56002-71-2 trimethyl-(1H,1... CAS#:67-56-1 Methanol CAS#:116-14-3 Tetrafluoroethylene
DownStream 9	Previous 1/3 Next
CAS#:3830-74-8 2,2,4,4,6-penta... CAS#:19493-30-2 1H,7H-PERFLUORO... CAS#:28393-02-4 10,12-DOCOSADIY... CAS#:2355-57-9 bis(1h,1h,7h-pe...

HS Code	2905590090
Summary	2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1H,1H,7H-Dodecafluoro-1-heptanol

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol

MFCD00039630

1,1,7-Trihydrododecafluoroheptan-1-ol

EINECS 206-406-6

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptanol

1,1,7-Trihydroperfluoroheptanol

1h,1h,7h-dodecafluoroheptanol

1H,1H,7H-Perfluoroheptan-1-ol

7,7,6,6,5,5,4,4,3,3,2,2-Dodecafluoroheptanol

2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-1-heptanol

1-Heptanol,2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro

1-Heptanol, 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-

1,1,7-Trihydrododecafluoroheptanol

2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

3. Shipping

4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137

Company Profile Introduction

Recommended supplier

Send Inquriy

1H,1H,7H-DODECAFLUORO-1-HEPTANOL NEW

Names

Ixazomib (MLN2238) Biological Activity

Chemical & Physical Properties

Names

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms

Company Profile Introduction

You may like

Recommended supplier