1-nitrosopiperazine NEW

• DATA ITEMS CITED :

• 9

• MOLECULAR FORMULA :

• C4-H9-N3-O

• MOLECULAR WEIGHT :

• 115.16

• WISWESSER LINE NOTATION :

• T6M DNTJ DNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 2260 mg/kg

• TOXIC EFFECTS :

• Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - acute pulmonary edema Liver - fatty liver degeneration

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 5400 mg/kg/60W-I

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Reproductive - Tumorigenic effects - uterine tumors

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 720 mg/kg/20W-I

• TOXIC EFFECTS :

• Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 1400 mg/kg/60W-I

• TOXIC EFFECTS :

• Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - tumors

MUTATION DATA

• TYPE OF TEST :

• Host-mediated assay

• TEST SYSTEM :

• Rodent - mouse Bacteria - Escherichia coli

• DOSE/DURATION :

• 150 mg/kg

• REFERENCE :

• MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 272,161,1992