化合物 PALOSURAN HYDROCHLORIDE
化合物 PALOSURAN HYDROCHLORIDE
化合物 PALOSURAN HYDROCHLORIDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：50 mg/mL（109.89 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Water: 7.14 mg/mL (15.69 mM) |
化合物 PALOSURAN HYDROCHLORIDE 用途与合成方法
IC50: 3.6 nM (human urotensin II receptor)
Palosuran (8 h) inhibits
125
I-U-II binding to human UT receptor, with IC
50
s of 46.2 nM on TE 671 cells and 86 nM on recombinant CHO cells.
Palosuran inhibits Ca
2+
mobilization in response to human U-II in CHO cells expressing human and rat UT receptor with IC
50
s of 17 and >10000 nM, respectively.
Palosuran (0.12-10000 nM; 20 min) inhibits human U-II induced MAPK phosphorylation in a dose-dependent manner in recombinant CHO cells, with an IC
50
of 150 nM.
ACT-058362 (10 mg/kg/h; i.v.) fully prevents the decrease in renal blood flow after ischemia in rats without decreasing blood pressure.
Palosuran (300 mg/kg/d; p.o. for 16 weeks) improves the survival, increases insulin, and slows the increase in glycemia, glycosylated hemoglobin, and serum lipids in streptozotocin-induced diabetic rats.
| Animal Model: | Male Wistar rats with renal ischemia and reperfusion |
| Dosage: | 20 mg/kg/h for 135 min |
| Administration: | I.v. (continuous infusion) for 135 min |
| Result: |
Restored renal blood flow to baseline values at 30 min after reperfusion and by 60 min increased renal blood flow by 12% above baseline values.
Did not significantly alter mean arterial blood pressure (MAP) and heart rate (HR). |
化合物 PALOSURAN HYDROCHLORIDE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-10655A | 化合物 PALOSURAN HYDROCHLORIDE | 2469274-58-4 | 5mg | 720 |
| 2026-09-15 | HY-10655A | 化合物 PALOSURAN HYDROCHLORIDE | 2469274-58-4 | 10mg | 1350 |
