HPB is a selective inhibitor of HDAC6 deacetylase.
HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].
HDAC6: 31 nM (IC50); HDAC1: 1130 nM (IC50)
[1] Nicholas J Porter, et al. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13459-13464. DOI:
10.1073/pnas.1718823114
