GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.1,2 They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.2,3 The γ2 subunit is the most abundant subunit in the brain and is required for clustering and postsynaptic localization of α1 or α2 subunit-containing GABAA receptors in mouse brain.4 Mutations in GABRG2, the gene encoding the γ2 subunit, have been found in patients with childhood absence epilepsy (CAE), genetic epilepsy with febrile seizures plus (GEFS+), Dravet syndrome, and idiopathic genetic generalized epilepsy (GGE).2 Cayman’s GABAA Receptor γ2 Subunit Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor γ2 subunit at approximately 46 kDa from mouse and rat samples.WARNING This product is not for human or veterinary use.
