2-(2-aminoethyl)phenol

Product Name2-(2-aminoethyl)phenol
CAS2039-66-9
MFC8H11NO
MW137.18
EINECS218-016-3
MOL File2039-66-9.mol

Chemical Properties

Melting point	113-115 °C
Boiling point	258.0±15.0 °C(Predicted)
Density	1.103±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	9.41±0.35(Predicted)
Appearance	Off-white to yellow Solid
InChI	InChI=1S/C8H11NO/c9-6-5-7-3-1-2-4-8(7)10/h1-4,10H,5-6,9H2
InChIKey	FMEVAQARAVDUNY-UHFFFAOYSA-N
SMILES	C1(O)=CC=CC=C1CCN

Usage And Synthesis

Description

2-Hydroxyphenethylamine (also known as phenylethanolamine) is a kind of trace amine found in the brain. It may modulate the sympathetic functions. It has strong cardiovascular activity, and can be used as a drug to produce topical vasoconstriction. Its derivatives are adrenergic agonists and antagonists, and have the potential for the treatment of respiratory diseases.

Uses

2-(2-aminoethyl)phenol is a ortho-hydroxylated phenylethylamine present in urine of patients with affective disorder following (MAO-inhibiting) antidepressant drug treatment. It has been used in studies as a substrate of monoa mine oxidase B and was revealed to be a potential inactivator of MAO-B.

Uses

A ortho-hydroxylated phenylethylamine present in urine of patients with affective disorder following (MAO-inhibiting) antidepressant drug treatment. It has been used in studies as a substrate of monoamine oxidase B and was revealed to be a potential inactivator of MAO-B.

Definition

ChEBI: 2-(2-aminoethyl)phenol is a primary amine.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2502, 1976 DOI: 10.1021/jo00876a038

References

https://en.wikipedia.org/wiki/Phenylethanolamine
Biggadike, Keith, et al. "PHENYLETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES." WO, EP 1556340 A1. 2005.
https://pubchem.ncbi.nlm.nih.gov/compound/2-Amino-1-phenylethanol#section=Top